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The authors have evaluated experimentally tabal sterilization in the rabbit fallopian tube, applicating 1%, 3% and 10% sodium hydroxide and 5% and 10% salicylic acid in solution. After laparotomy under thiopenthal intravenously. or ether open dropping anesthesia, the using chemical was administered in the uterine cornus with a fine-gauge needle and the syring was maintained in position for approximately the seconds. Laparotomy after application of chemical into tube was made 1 to 5 weeks interval, then rabbits were not killed while hysterctomy was taken. In histological examination of the tubes, there were extensive tissue adhesive, fibrosis, destruction or regeneration of epithelial cells of the tubal mucosa and narrowing or complete obliteration of the tubal lumen. For one rabbit, one side of the tubes was treated with 1% sodium hydroxide and the other was not treated. Two weeks after the procedure, the rabbit was mated and we found five embryos in the not treated uterine horn and no embryos in the treated side. It appears that chemical tubal sterilization was simple, low cost and not required faciliated setting so it seems to be promised satisfactory effectiveness in the rabbit or evev in human.
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